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Mutations in the fibrillin-1 gene (FBN1) are associated with various heritable connective tissue disorders (HCTD). The most studied HCTD is Marfan syndrome. Ninety percent of Marfan syndrome is caused by mutations in the FBN1 gene. The zebrafish share high genetic similarity to humans, representing an ideal model for genetic research of human diseases. This study aimed to generate and characterize fbn1 mutant zebrafish using the CRISPR/Cas9 gene-editing technology. CRISPR/Cas9 was applied to generate an fbn1 frameshift mutation (fbn1 )
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