https://stat-receptor.com/mole....cularly-imprinted-po
Chromosome conformation capture (3C)-based experiments coupled with computational modelling are crucial for unveiling 3D chromosome structure. Here, we introduce TADdyn, something that combines time-course 3C data, restraint-based modelling, and molecular characteristics to simulate the architectural rearrangements of genomic loci in a completely data-driven way. We use TADdyn on in situ Hi-C time-course experiments learning the reprogramming of murine B cells to pluripotent cells,