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We found that substitution mutation damaged vascular endothelial growth factor (VEGF) secretion and the downstream JAK1/STAT3 activation, the binding capacity to Von Willebrand factor (VWF), cell proliferation, migration, and vascular tube development. Overall, our study concluded that Trp387 and Trp390 of ADAMTS13 perform important roles when you look at the biological purpose of ECs. This informative article is shielded by copyright. All legal rights reserved.Strigolactone