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In the paper the positivity problem of the model of an one dimensional heat transfer process is addressed. Such a problem has not been considered yet. The considered thermal process is described by the fractional order state equation, derived from parabolic heat equation with homogenous Neumann boundary conditions and distributed control and observation. The internal and external positivity of the model depend on heater and sensor location as well as the size of the model. It is proved that the external positivity of the considered syste

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elegans, DUD-E and DrugBank show our method outperforms the state-of-the-art method in terms of AUC, Precision, Recall, Recall, AUPR and F1-score. In addition, the case studies further demonstrate that our method can provide effective visualization to interpret the prediction results from biological insights.Pancreatic cancer is a significant cause of cancer-related deaths in the United States with an abysmal 5-year overall survival rate that is under 9%. Reasons for this mortality include the lack of late-stage treatment options and