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ssfully treated with standardized long term regimen. Further prospective cohort study is required to investigate factors contributing to death or treatment failure.BACKGROUND It has been claimed that efficacy estimates based on the Hamilton Depression Rating-Scale (HDRS) underestimate antidepressants true treatment effects due to the instrument's poor psychometric properties. The aim of this study is to compare efficacy estimates based on the HDRS with the gold standard procedure, the Montgomery-Asberg Depression Rating-Scale (MADRS). MET

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is a commonly used traditional Chinese medicine in China, which has been widely applied to enhance the immunomodulatory function of the body. The main bioactive components are complicated. To explore the role of the components, various techniques have been applied in extraction. Membrane separation technique featured with green processing condition and high efficiency is of signification interest in the application of treatment. In this study, a new ingredients group A4 was separated from using membrane separation technique. The qu