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ive cultural zeitgeist that exists in peer-review. The current research-care separation was introduced to protect patients from explanatory studies designed to gain knowledge for future patients. Care trials are all-inclusive pragmatic trials integrated into medical practice, with no extra tests, risks, or cost, and have been designed to guide practice under uncertainty in the best medical interest of the patient. Patients need a distinction between validated care, previously verified to provide better outcomes, and promising but unvalida