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But, forecasting exactly how phage cocktails influence microbial communities with complex environmental interactions, especially cross-feeding communications in which micro-organisms exchange nutrients, stays challenging. Right here, we used experiments and mathematical simulations to determine how to best suppress a model pathogen, E. coli, when obligately cross-feeding with S. enterica. We tested whether the extent of pathogen suppression brought on by a two-lytic phage cocktail ended u