https://www.selleckchem.com/pr....oducts/selonsertib-g
In addition, the activating and repressive chromatin marks H3K4me3 and H3K27me3, respectively bind mutant and wildtype alleles exclusively. Lastly, in heterozygous mutant cell lines, TERT exhibits monoallelic expression from the mutant allele only. CONCLUSIONS In summary, by employing new long read sequencing methods, we were able to definitively demonstrate allele-specific DNA methylation, histone modifications, transcription factor binding, and the resulting mono-allelic transcription in cell lines with heterozygous TERT m

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