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End-stage renal disease (ESRD) and the need for haemodialysis (HD) treatment are increasing. The course of the disease and all the life readjustments needed may generate a multitude of fears in patients and families. This study aimed to explore the main fears and concerns of patients with ESRD undergoing HD and their family members. A qualitative study was performed. Individual semi-structured interviews were conducted with three groups 20 patients, 14 family caregivers and 15 patient-family dyads. Interviews were audiotaped, transcribe