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One of the hallmarks of primary Sjogren's syndrome (pSS) is the presence of various autoantibodies in patients' serum, including traditional autoantibodies for disease diagnosis and classification, autoantibodies associated with other autoimmune diseases, and the novel autoantibodies identified from mouse models. The autoantibodies are closely related to the diagnosis, prognosis, and clinical manifestations of pSS. There are significant differences in the prevalence and clinical correlations between anti-Ro60 antibody and anti-Ro52 antibo