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Radiotherapy into the pelvis can result in radiation-induced vaginal soft tissue necrosis. This dramatically impacts quality of life. Scientific studies assessing the efficacy of HBO2 are limited. In this retrospective report, we evaluated the health files of patients addressed with once-daily HBO2 for radiation-induced genital soft tissue necrosis. We included females between the ages of 18 to 90 with history of pelvic disease addressed with radiotherapy and resultan