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with advanced lung cancer. The innovation of this article is that although the patient has advanced cancer and ECOG PS 4 is an end-stage patient, immunotherapy is still given and achieved great success.Extensive necrosis of lower extremity muscles through the clinical practice of limb salvage after a case of high level crushing injury. A case of car accident injury complicated with necrotizing fasciitis, myositis, and septic shock was admitted to our hospital. The pathogenic factors, clinical characteristics, and surgical