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In contrast, no acceleration of the ORR rate with syn -Me 2 Iph by external protons was observed. The different mechanisms in the O 2 reduction by the two isomers should be derived from that of the arrangement of hydrogen bonding of a O 2 with inner N H protons of the isophlorins. © 2020 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim.BACKGROUND Biologic therapies in patients with Crohn's disease often yield low clinical and endoscopic remission rates. After multiple failed therapies, combining two biologic therapies is possibly the sole m