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21; 95% CI 0.06-0.75; P = 0.020; I2 = 0%). The initial transection line was changed in 7.62% (31/407) of patients in the ICG group and 19.35% (6/31) of patients suffered AL. In transection line unchanged patients (376/407), 5.05% (19/376) of patients suffered AL. CONCLUSION Intraoperative use of ICG FA is associated with lower incidence of AL after LAR. The benefit of ICG FA may be that it could identify patients with high risk for AL. © 2020 Royal Australasian College of Surgeons.INTRODUCTION Diagnosis of von Willebrand disease