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We report an exceedingly rare case of primary SEF in the right fibula and its radiological features with CE-CT and MRI. We report an exceedingly rare case of primary SEF in the right fibula and its radiological features with CE-CT and MRI. A new combination therapy consisting of intraarterial chemotherapy plus radiotherapy was demonstrated to have the potential to improve the response rate and survival time in patients with unresectable biliary tract cancer. We retrospectively investigated the effectiveness and safety of a new combinatio