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Third, ventricular size and EF/attention associations were absent in the high APOE+ PP risk group both concurrently and longitudinally. As AD progresses, a threshold effect may be present in which ventricular enlargement in the context of exacerbated APOE+ PP risk does not produce further cognitive decline. As AD progresses, a threshold effect may be present in which ventricular enlargement in the context of exacerbated APOE+ PP risk does not produce further cognitive decline. Behavioral and psychological symptoms of dementia (BPSD) hav