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001). The forehead and chin regions presented with the largest significant difference, 3.5 mm ( = .002) and 3.2 mm ( .001), respectively; followed by the eye (2.4 mm; = .004), cheek (2.2 mm; = .004), nose (1.7 mm; = .001), and mouth (1.4 mm; = .009) regions. The transverse direction presented with the largest significant difference in the forehead, chin, mouth, and nose regions, the sagittal direction in the cheek region, and the vertical direction in the eye region. Muenke syndrome-associated unicoronal synostosis presented with