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Zebrafish scales are classified as dermal bone tissue and potentially represent a convenient animal type of GIOP since they quickly regenerate after their treatment. We clarified that dexamethasone-treated regenerating scales revealed malformations, decreased dimensions and circularity. Anti-osteoporosis drugs rescued the scale malformation phenotype eight-days after the elimination of scales. Thus, the dexamethasone-induced regenerating scale malformation design may be a helpful animal model