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brucei. Together, these data provide insight in the way in which different parts of T. cruzi metabolism, although uniquely distributed over different compartments, are integrated and regulated. Moreover, this information reveals opportunities for the development of drugs against Chagas disease caused by these parasites and for which currently no adequate treatment is available. Copyright © 2020 Quiñones, Acosta, Gonçalves, Motta, Gualdrón-López and Michels.Background and Aims Continuous development will evolve into end-stage liver diseas