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We found that ibogaine and noribogaine induced a dose- and time-dependent antidepressant-like effect without significant changes of animal locomotor activity. Noribogaine's FST effect was short lived (30 minutes) and correlated with high brain concentrations (estimated 8 M of free drug), while the ibogaine's antidepressant-like effect was significant at 3 hours. At this time point, both ibogaine and noribogaine were present in rat brain at concentrations that cannot produce the same behavioral outcome on their own (ibogaine ~ 0.5 

https://click4r.com/posts/g/18....006180/10-mistaken-a
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