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ADHD Medications - Stimulant Or Non Stimulant? Stimulant medications are the first-choice ADHD treatment, because they're the most studied and have a rapid-acting effect. However, they're not suitable for everyone. These medications boost the communication between brain regions and nerves to decrease ADHD symptoms. These medications can also cause negative side effects, such as a rise in heart rate or blood pressure as well as a loss of appetite. Stimulants Stimulants are among the most popular medications used to treat ADHD. They're know