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Postmenopausal ladies (n= 110,992) elderly 50-79years without diabetic issues at registration into the Women's Health Initiative research (1993-1998) were used up to 25years. Incident diabetes was evaluated via a validated self-report of physician-diagnosed diabetes addressed with insulin or any other hypoglycemic medicines. Mediation analyses were carried out using approaches under a counterfactual framework. An inverse relationship of optimism with diabetes was dramatically mediated by a factor mostly