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Cerebral microbleed (CM is an increasingly important risk factor for cognitive impairment due to population aging. Controversies, however, remain regarding the exact association between CMB and cognitive dysfunction. We aimed to determine the relationship between CMB burden and cognitive impairment, and also explore the characteristics of cognitive decline in CMB patients for middle-aged and elderly people. The present cross-sectional study included 174 participants (87 CMB patients and 87 controls) who underwent brain magnetic resona