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Materials and practices Four databases (Cochrane Library, PubMed, internet of Science, and Scopus) were systematically searched until 14 November 2022, without having any restrictions. The Joanna Briggs Institute (JBI) crucial assessment checklist modified for case−control studies had been made use of to evaluate the caliber of the reports. The result sizes were extracted making use of the Review Manager 5.3 software for the bloodstream levels of OM-1 and OXA in aOSA