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87, 95% CI 1.79-4.61, P0.001) and serum procalcitonin levels (odds ratio =13.50, 95% CI 1.22-149.57, P=0.034) were independently associated with refractory pneumonia. Defervescence after minocycline treatment was significantly longer among the refractory pneumonia group than in the non-refractory pneumonia group (median 2 1 day, P0.001). Only one case (0.7%) suspected of a side effect of minocycline therapy was observed. Two risk factors independently associated with refractory pneumonia were determined. Early use of minocyclin
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