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Introduction. Nikkomycin Z (nikZ) is a chitin synthase inhibitor. Efficacy against Coccidioides has been demonstrated in animal models of pulmonary or brain infection. Its short half-life, in mice and humans, would necessitate divided daily dosing. We assayed nikZ efficacy in disseminated coccidioidomycosis (in a reduction of CFU design), and whether sustained release might be useful. Methods. Mice were challenged intravenously, with low or high arthroconidial inocula. Fluconazole, clinically the most commonly used anti-coccidioidal drug, was compar