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Forty metabolites were tentatively characterized in the bioactive fractions using UPLC-PDA-ESI-MS. 5,6,4'-trihydroxy-3',7,8-trimethoxy flavone was isolated from Ml as a first report, in addition to 5,6-dihydroxy-3',4',7,8-tetramethoxy flavone and rosmarinic acid. These findings suggest that Ml is a promising nutraceutical and source of lead compounds halting AD progression. PRACTICAL APPLICATIONS The results presented in this paper unravels the neuroprotective effect of Mentha longifolia fractions and oil by acting as anti-inflammator