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Objective To analyze the risk factors of hypoparathyroidism after total thyroidectomy. Methods Clinical data of patients who undergo total thyroidectomy in the Luwan Branch of Ruijin Hospital Affiliated to Medical College of Shanghai Jiaotong University was collected from January 2015 to December 2018, retrospectively. Logistic regression was used to analyze the risk factors associated with transient and long-term hypoparathyroidism. Results A total of 537 patients were collected. The patients' average age included in the study was 47.3 ± 12.7 years old, in