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41, 2.62) and a fall injury (OR 1.67; 95% CI 1.09, 2.55) over two years. Indirect effect estimates showed that antidepressant medication use accounted for approximately 19% and 18% of the association between MDD and falls and fall injuries, respectively. Results were similar when using an alternative depression measure and when considering only selective serotonin reuptake inhibitor antidepressants. Antidepressant use explains a significant proportion, but not a majority, of the association between depression and greater fall risk. Treatm