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This work demonstrates the interfacial diffusion behavior and system of hydrated ions during the molecular level, which could offer important assistance in nanosensors, seawater desalination, as well as other hydrated ion-related industries.Herein we present the results of an in-depth simulation study of LinA as well as its two alternatives. Within our analysis, we blended the research of necessary protein conformational characteristics with and without certain substrates (hexachlorocyclohexane (HCH) is