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5 mm [OR 1.080 (95% CI 1.021-1.142), P=0.007] and flat/depressed shape [OR 0.206 (95% CI 0.076-0.564), P=0.002] were significantly associated with histopathologic discrepancies in EFB. Conclusions EFB was of limited clinical value in identifying the preoperative diagnosis of rectal lesions. Lesions thickness and flat/depressed shape at EFB were independent risk factors for pathologic discrepancies. TRUS-guided CNB may serve as a safe and effective supplement to routine EFB. 2019 Annals of Translational Medicine. All rights reserved.Backg
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