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. Describe patterns in the dissemination of fake news in the context of COVID-19 mortality and infodemic management in six Latin American countries. A descriptive ecological study explored the percentage of the population that is unable to recognize fake news, the percentage who trust social network content, and the percentage who use it as their sole news source in Argentina, Brazil, Chile, Colombia, Mexico, and Peru, up to 29 November 2020. Internet penetration rate, Facebook penetration rate, and COVID-19 mortality were calculated for