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001). Higher percentages of NF-200-positive neurons in the DRG were c-Fos immunoreactive in the DPN-with-MA group than in the DNP-without-MA group (p=0.014). The numbers of c-Fos-immunoreactive neurons in both the superficial (I-II) and deeper (III-V) laminae of the SDH in the DPN-with-MA group were larger than those in the subgroups without MA (p0.001). The impairment of primary myelinated fibres and the pattern of neuronal activation in both the DRG and the SDH are specific features that differentiate diabetic rats with MA from th