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To advance understand the cornerstone among these neurologic problems, we investigated the consequences of combined radiotherapy and TMZ chemotherapy (combined treatment) on neurological impairments using a mouse design. Five days after combined treatment, mice displayed anxiety-like habits, and also at 15 weeks both anxiety- and depression-like behaviors had been seen. Strongly related the recognized roles of the serotonin axis in mood disorders, we unearthed that 5HT1A