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0%; TLE-HS 9.9%; encephalomalacia 16.7%; P  0.001). The etiology of FCD (p  0.001) was significantly associated with SRE (OR 9.71, 95% CI 3.35-28.14) as an independent risk factor. In addition, small lesion size (p = 0.009) of FCD further increased the risk of SRE (OR 3.18, 95% CI 1.33-7.62) in the FCD group. Our data highlight that FCD markedly increased the risk of sleep-related epilepsy independently of seizure localization. A small lesion of FCD further increased the risk of sleep-related epilepsy by 2.18 times in the FCD