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The evolved method features high sensitiveness because the reduced limit of measurement ranged from 0.05 to 0.50 ng mL-1 along with the reliability and precision predicted within 88.88-111.25% and 1.03-11.82%, correspondingly. A credit card applicatoin of a straightforward and fast liquid-liquid extraction procedure for sample cleaning lead to an extremely satisfactory recovery associated with analytes (88.30%). Also, the method ended up being validated using synthetic plasma, an approach tha