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443; P .001), N1 classification (HR 2.310; P .001), M1 classification (HR 3.357; P .001), and positive surgical margins (HR 1.454; P .001) were survival prognosticators. Adjuvant radiotherapy use was negatively correlated with older age, oral cavity localization, and M0 or T3 tumors (all P .05). Adjuvant immunotherapy use was positively correlated with younger age and M1 tumors (all P .05). Although SR did not confer survival benefits in HNMM patients, SI and SRI yielded greater OS than surgery alone. SRI was associ