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Identifying risk factors for SARS-CoV-2 infection could help health systems improve testing and screening strategies. Identify demographic factors, comorbid conditions, and symptoms independently associated with testing positive for SARS-CoV-2. Observational cross-sectional study. Veterans Health Administration. Persons tested for SARS-CoV-2 nucleic acid by polymerase chain reaction (PCR) between March 1 and May 14, 2020. Associations between demographic characteristics, diagnosed comorbid conditions, and documented symptoms with testin