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the shear bond strength to dentin when applied using the total-etch or self-etch modes. Tetric N-Bond showed significant deterioration in bond strength when applied in the total-etch mode and exhibited the highest bond strength when applied in the self-etch mode. To assess the tear levels of inflammatory cytokines in patients with keratoconus (KC). Systemic review and meta-analysis. The following electronic databases and search engine were searched PubMed, EMBASE, Web of Science, and Google Scholar. A systematic search of all relevant s