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No study was fully free of bias. No effect was found on quality of life (standardized mean difference [SMD] 0.05; 95% CI -0.05 to 0.16) and hospital admission (risk ratio [RR] 0.87; 95% CI 0.65 to 1.17). There was a very small effect for patients' satisfaction (SMD 0.15; 95% CI 0.00 to 0.29) and caregiver burden (SMD -0.13; 95% CI -0.26 to 0.0. Certainty of evidence was low for all outcomes. No firm conclusions can be reached about the effects of goal-oriented care for multimorbid adults. Future research should overcome the shortcom