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Purpose Develop a quantitative image analysis method to characterize the heterogeneous patterns of nodule components for the classification of pathological categories of nodules. Materials and methods With IRB approval and permission of the National Lung Screening Trial (NLST) project, 103 subjects with low dose CT (LDCT) were used in this study. We developed a radiomic quantitative CT attenuation distribution descriptor (qADD) to characterize the heterogeneous patterns of nodule components and a hybrid model (qADD+) that combined qADD