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Recent studies have confirmed that at least two pain inhibitory pathways are activated from the anterior pretectal nucleus. This review focuses on rodent anatomical, behavioral, molecular, and neurochemical data that have helped to identify mediators of the anterior pretectal nucleus and pathways related to its role in pain modulation. To estimate annual weight gain and the incidence of overweight and obesity, stratified according to gender and socioeconomic factors. From the Brazilian Longitudinal Study of Adult Health (E