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© 2020 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim.SCOPE This review represents a focus on the structure and properties of the common nutritional disaccharides (lactose, maltose and sucrose) in health and disease. The aim is to provide a comprehensive reference source related to the role of disaccharides in human nutrition. METHODS AND RESULTS Key reference sources were searched including Web of Science, PubMed, Science Direct, Wiley Online etc. and key reference works were selected to support the factual basis of the text where in