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Through the use of an animal model of allergic asthma in IL-4-reporter mice, we found that Th2 cells into the lung expressed greater amounts of Rora compared to those into the lymph nodes, and that treatment with an RORα agonist SR1078 lead to reduced Th2 cell responses in vivo. To determine the T cell-intrinsic role of RORα in allergic asthma in vivo, we established T cell-specific RORα-deficient (Cd4creRoraf/f) mice. Upon intranasal allergen challenges, Cd4creRoraf/f mice exhibited a significan
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