https://www.selleckchem.com/pr....oducts/2-3-butanedio
TGF-β1 induced a continuous and significant decrease of ADAMTS-7. Inversely, IL-1β up-regulated the ADAMTS-7 level in a dosage dependent manner. In addition, knockdown of ADAMTS-7 inhibited the growth and invasion of HTR8/SVneo cells. To the contrary, ADAMTS-7 overexpression promoted the growth and invasion of HTR8/SVneo cells. ADAMTS-7 knockdown led to a decreased level of FAK Tyr-397 phosphorylation. DISCUSSION Our results suggest that ADAMTS-7 may regulate trophoblasts invasion through focal adhesion kinase (FAK) s
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