https://www.selleckchem.com/products/GDC-0449.html
V36M/L,Q80L,S122G/L,R155T/G,A156S,D168Y/N and S174A/N/T mutations were detected in this study. Although the prevalence of RASs was totally low in this study, the presence of several cases of double and triple mutants among this population suggests prior evaluation of protease inhibitors related mutations before initiation of standard treatment and also investigation on a large population could be of high value. Although the prevalence of RASs was totally low in this study, the presence of several cases of double and triple mutants amon