https://www.selleckchem.com/pr....oducts/pf-06700841.h
5, 25, 50, 100 and 200 μg/mL 5-FU resulted in significantly higher proliferation inhibition rates than in the cells transfected with the control siRNA ( 0.01). BIRC6 silencing also significantly increased the apoptosis rate of 786-O cells following 5-FU treatment ( 0.01). The results of Western blotting showed that BIRC6 silencing significantly lowered the protein expressions of Beclin and LC3A/B in 786-O cells. Interference of BIRC6 mediated by siRNA can inhibit autophagy and promote 5-FU-induced apoptosis to enhance the
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