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4%) from those with a sharp nozzle geometry ( = 0.005). Adjusting the instillation angle of eyedrop solutions to 90°, as well as using a nozzle geometry that prevents flow of the solution to the side of the bottle, significantly reduced contamination rates. Standardizing drop bottles and adjusting delivery angle shows promise in reducing contamination rates and may critically impact the quality of care for patients requiring topical therapeutic agents. Standardizing drop bottles and adjusting delivery angle shows promise in reducing con