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In this review, we summarize the latest literature on the role of these bacteria in cancer treatment. Probiotics and their metabolites (SCFA) can regulate energy homeostasis. The present study thus evaluates the synergistic effect of probiotic Enterococcus faecalis AG5 on HFD induced obesity and the role of propionic acid (PA) in apoptosis induction of 3T3-L1 pre-adipocyte. Male Wistar rats (n=24) were used to develop an HFD induced obesity model for 24weeks. The effect of the orally administered probiotic AG5 (18th-24th weeks, 1×10 CFU/ml