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7% patients in the CD group and 60.7% patients in the UC group who achieved steroid-free remission. This study demonstrates the effectiveness and safety of VDZ as a first-line biological, particularly among elderly patients. This study demonstrates the effectiveness and safety of VDZ as a first-line biological, particularly among elderly patients.Background It is important to properly understand the molecular mechanisms of aggressive tumors among papillary thyroid carcinomas (PTCs) that are often the most indolent. Hypoxia inducible fact